誠司さん：
Asymmetry and aging of mycobacterial cells lead to variable growth and antibiotic susceptibility. Science, 2012 Jan 6; 6064:100-4
Mycobacterial infections cause serious diseases in mammals, including tuberculosis. Authors found the mycobacterial cell division cycle is governed by the same time, and one generation of birth is about 3 hours. However, division of the asymmetrically growing mother cell gives rise to daughter cells that differ in elongation rate and size. Thus, the distinction of sister cells decides that they have different antibiotic susceptibility and this conclusion lets us know that even for the same generation, we should take differential treatment for mycobacteria.
Cytoplasmic Dynein Moves Through Uncoordinated Stepping of the AAA+ Ring Domains. Science 13 January 2012:Vol. 335 no. 6065 pp. 221-225
Dynein is a motor protein in cells which converts the chemical energy contained in ATP into the mechanical energy of movement. Dynein transports various cellular cargo by "walking" along cytoskeletal microtubules towards the minus-end of the microtubule, which is usually oriented towards the cell center. Before, the movement of dynein is considered as being like the hand-over-hand stepping of kinesin and myosin. But this paper shows that dynein moves processively without interhead coordination. Their conclusion changes our understanding about dynein movement.
小林さん：
F1Fo-ATPase, F-type proton-translocating ATPase, at the plasma membrane is critical for efficient influenza virus budding. PNAS Vol.109 no 12
They used siRNA method to mediate down-regulation of the _ subunit of the F1Fo-ATPase and then reduced formation of influenza virion and virus growth in cell culture were found. So they get one conclusion that efficient influenza virion formation requires the ATPase activity of F1Fo-ATPase. But, to my surprise, a critical component in host, membrane-associated F1Fo-ATPase actually is helpful for efficient influenza virus replication inside of itself.