小原圭介, 細胞膜脂質非対称の感知と細胞応答, アグリバイオ, 5 (2) : 43-46 (2021)

Obara K and Kamura T., The Rim101 pathway mediates adaptation to external alkalization and altered lipid asymmetry: hypothesis describing the detection of distinct stresses by the Rim21 sensor protein.　Curr Genet, doi:10.1007/s00294-020-01129-0 (2020)

Hori T., Cao J., Nishimura K., Ariyoshi M., Arimura Y., Kurumizaka H and Fukagawa T., Essentiality of CENP-A Depends on Its Binding Mode to HJURP.　Cell reports, http://dx.doi.org/10.2139/ssrn.3544132 (2020)

Obara K., Higuchi M., Ogura Y., Nishimura K., Kamura T., Rapid turnover of transcription factor Rim101 highlights a flexible adaptation mechanism against environmental stress in Saccharomyces cerevisiae.　Gene Cells, 25: 651-662 (2020)

Nishimura, K., Yamada, R., Hagihara, S., Iwasaki, R., Uchida, N., Takahashi, K., Kamura, T., Torii, UK., and Fukagawa T. A super-sensitive auxin-inducible degron system with an engineered auxin-TIR1 pair Nucleic Acids Research, gkaa748. https://doi.org/10.1093/nar/gkaa748. (2020)

Nishimura, K., Yamada, R., Hagihara, S., Iwasaki, R., Uchida, N., Takahashi, K., Kamura, T., Torii, UK., and Fukagawa T. A super-sensitive auxin inducible degron system with an engineered auxin-TIR1 pair bioRxiv, doi: https://doi.org/10.1101/2020.01.20.912113. (2020)

Obara K., Kotani T., Nakatogawa H., Kihara A., and Kamura T., N-glycosylation of Rim21 at an unconventional site fine-tunes its behavior in the plasma membrane. 　Cell Struc Func, 45 1-8. DOI: https://doi.org/10.1247/csf.19021 (2020)

Nishimura, K., Komiya, M., Hori, T., Itoh, T., and Fukagawa T. 3D genomic architecture reveals that neocentromeres associate with heterochromatin regions. Journal of Cell Biology, 218(1) , 134-149, doi: 10.1083/jcb.201805003. (2019)

Nakatsukasa, K., Sone, M., Alemayehu, DH., Okumura, F., and Kamura T. The HECT-type ubiquitin ligase Tom1 contributes to the turnover of Spo12, a component of the FEAR network, in G2/M phase. FEBS Lett. 592(10):1716-1724. doi: 10.1002/1873-3468.13066. (2018)

Okumura, F., Joo-Okumura, A., Obara, K., Petersen, A., Nishikimi, A., Fukui, Y., Nakatsukasa, K., and Kamura, T. Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2. Mol Biol Cell. 28(24):3532-3541. doi: 10.1091/mbc.E17-07-0450. (2017)

Okumura, F., Joo-Okumura, A., Nakatsukasa, K., and Kamura, T. Hypoxia-inducible factor-2α stabilizes the von Hippel-Lindau (VHL) disease suppressor, Myb-related protein 2. PLos One  12(4):e0175593. doi: 10.1371/journal.pone.0175593.  (2017)

Uematsu, K., Okumura, F., Tonogai, S., Okumura, AJ., Alemayehu, DH., Nishikimi, A., Fukui, Y., Nakatsukasa, K., and Kamura, T. ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation. J Cell Biol 215(1):95-106. DOI: 10.1083/jcb.201603062. (2016)

Okumura, F., Uematsu, K., Byrne, SD., Hirano, M., Joo-Okumura, A., Nishikimi, A., Shuin. T., Fukui, Y., Nakatsukasa, K., Kamura, T. Parallel regulation of VHL disease by pVHL-mediated degradation of B-Myb and HIF-α. Mol.Cell.Biol., 36(12):1803-17. doi: 10.1128/MCB.00067-16. (2016)

Okumura, F., Okumura, AJ., Nakatsukasa, K., Kamura, T. The role of cullin 5-containing ubiquitin ligases. Cell Division. 11:1 DOI 10.1186/s13008-016-0016-3. (2016)

Nakatsukasa K, Kamura T. Subcellular Fractionation Analysis of the Extraction of Ubiquitinated Polytopic Membrane Substrate during ER-Associated Degradation. PLoS One. 11(2):e0148327. doi: 10.1371/journal.pone.0148327. eCollection (2016)

Nakatsukasa, K., Nishimura, T., Byrne, D., Okamoto, M., Takahashi-Nakaguchi, A., Chibana, H., Okumura, F. and Kamura, T. The ubiquitin ligase SCFUcc1 acts as a metabolic switch for the glyoxylate cycle. Molecular Cell. 59:22-34 doi: 10.1016/j.molcel.2015.04.013. (2015)

Nakatsukasa, K., Okumura, F., Kamura, T. Proteolytic regulation of metabolic enzymes by E3 ubiquitin ligase complexes: lessons from yeast. Crit Rev Biochem Mol Biol. 2015 Nov-Dec;50(6):489-502. doi: 10.3109/10409238.2015.1081869. Epub 2015 Sep 11

Song, XJ., Kuroha, T., Ayano, M., Furuta, T., Nagai, K., Komeda, N., Segami, S., Miura, K., Ogawa, D., Kamura, T., Suzuki, T., Higashiyama, T., Yamasaki, M., Mori, H., Inukai, Y., Wu, J., Kitano, H., Sakakibara, H., Jacobsen, SE., Ashikari, M. : Rare allele of a previously unidentified histone H4 acetyltransferase enhances grain weight, yield, and plant biomass in rice. Proc Natl Acad Sci USA. 112:76-81. doi: 10.1073/pnas.1421127112 (2015)

Nakatsukasa, K., Kanada, A., Matsuzaki, M., Byrne, SD., Okumura, F., Kamura, T. : The nutrient stress-induced small GTPase Rab5 contributes to the activation of vesicle trafficking and vacuolar activity. J Biol Chem. 289(30):20970-8. doi: 10.1074/jbc.M114.548297 (2014)

Nakatsukasa, K., Kamura T., Brodsky, JL.: Recent technical developments in the study of ER-associated degradation. Current Opinion in Cell Biology. 29:82-91. doi: 10.1016/j.ceb.2014.04.008 (2014)

Sato Y, Yoshizato T, Shiraishi Y, Maekawa S, Okuno Y, Kamura T, Shimamura T, Sato-Otsubo A, Nagae G, Suzuki H, Nagata Y, Yoshida K, Kon A, Suzuki Y, Chiba K, Tanaka H, Niida A, Fujimoto A, Tsunoda T, Morikawa T, Maeda D, Kume H, Sugano S, Fukayama M, Aburatani H, Sanada M, Miyano S, Homma Y, Ogawa S.: Integrated molecular analysis of clear-cell renal cell carcinoma. Nature Genetics, 45(8):860-7. doi: 10.1038/ng.2699 (2013)

Nakatsukasa, K., Brodsky, JL., Kamura, T.: A stalled retrotranslocation complex reveals physical linkage between substrate recognition and proteasomal degradation during ER associated degradation. Mol Biol Cell. 24(11):1765-75 doi: 10.1091/mbc.E12-12-0907 (2013)

Okumura, F., Okumura, AJ., Uematsu, K., Hatakeyama, S., Zhang, DE., Kamura, T.: Activation of double-stranded RNA-activated protein kinase (PKR) by interferon-stimulated gene 15 (ISG15) modification down-regulates protein translation. J Biol Chem. 288(4):2839-47. doi: 10.1074/jbc.M112.401851 (2013)

Okumura, F., Matsuzaki, M., Nakatsukasa, K., Kamura, T.: The role of Elongin BC-containing ubiquitin ligases. Frontiers in Oncology. 2:10 doi:       10.3389/fonc.2012.00010 (2012)

Liu, Y., Nakatsukasa, K., Kotera, M., Kanada, A., Nishimura, T., Kishi, T., Mimura, S., Kamura, T.: Non-SCF type F-box protein Roy1/Ymr258c interacts with a Rab5-like GTPase Ypt52 and inhibits Ypt52 function. Mol. Biol. Cell. 22: 1575-1584 doi: 10.1091/mbc.E10-08-0716  (2011)

Mimura, S., Yamaguchi, T., Ishii, S., Noro, E., Katsura, T., Obuse, C., Kamura, T.: Cul8/Rtt101 forms a variety of protein complexes that regulate DNA damage response and transcriptional silencing. J. Biol. Chem. 285: 9858-9867 (2010)

Liu, Y., Mimura, S., Kishi, T., Kamura, T.: A longevity protein, Lag2, interacts with SCF complex and regulates SCF function. EMBO J. 28:3366-3377 (2009)

Mimura, S., Komata, M., Kishi, T., Shirahige, K., Kamura, T.: SCF^Dia2 regulates DNA replication forks during S-phase in budding yeast. EMBO J. 28:3693-3705 (2009)

Sato, Y., Kamura, T., Shirata, N., Murata, T., Kudoh, A., Iwahori, S., Nakayama, S., Isomura, H., Nishiyama, Y., Tsurumi T.: Degradation of phosphorylated p53 by viral protein-ECS E3 ligase comolex. PLoS Pathog. 5(7):e1000530 (2009)

Yasukawa, T., Kamura, T., Kitajima, S., Conaway, RC., Conaway, JW., Aso, T.:Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1. EMBO J. 27:3256-66 (2008)

Tsunematsu, R., Nishiyama, M., Kotoshiba, S., Saiga, T., Kamura, T., Nakayama, KI.: Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development. Mol. Cell. Biol. 26: 6157-6169 (2006)

Fujii, Y., Yada, M., Nishiyama, M., Kamura, T., Takahashi, H., Tsunematsu, R., Susaki, E., Nakagawa, T., Matsumoto, A., Nakayama, KI.: Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation. Cancer Sci. 97: 729-736 (2006)

Hara, T., Kamura, T., Kotoshiba, S., Takahashi, H., Fujiwara, K., Onoyama, I., Shirakawa, M., Mizushima, N., Nakayama, KI.: Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle. Mol. Cell. Biol., 25: 9292-9303. (2005)

Kotoshiba, S., Kamura, T., Hara, T., Ishida, N., Nakayama, KI.: Molecular dissection of the interaction between p27 and KPC, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase. J. Biol. Chem. 280: 17694-17700. (2005)

Kamura, T., Hara, T., Matsumoto, M., Ishida, N., Okumura, F., Hatakeyama, S., Yoshida, M., Nakayama, K., Nakayama, K.I.: Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27Kip1 at G1 phase. Nature Cell Biol. 6: 1229-35. (2004)

Kamura, T., Maenaka, K., Kotoshiba, S., Matsumoto, M., Kohda, D., Conaway, R.C., Conaway, J.W., Nakayama, K.I.: VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Genes Dev. 18: 3055-3065 (2004)

Okumura, F., Hatakeyama, S., Matsumoto, M., Kamura, T., Nakayama, K.I.: Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis. J. Biol. Chem. 279:53533-43. (2004)

Tamamori-Adachi, M., Hayashida, K., Nobori, K., Omizu, C., Yamada, K., Sakamoto, N., Kamura, T., Fukuda, K., Ogawa, S., Nakayama, K.I., Kitajima, S.: Down-regulation of p27Kip1 promotes cell proliferation of rat neonatal cardiomyocytes induced by nuclear expression of cyclin D1 and CDK4: Evidence for impaired Skp2-dependent degradation of p27 in terminal differentiation. J. Biol. Chem, 279: 50429-36. (2004)

Yan, Q., Kamura, T., Cai, Y., Jin, J., Ivan, M., Mushegian, A., Conaway, R.C., Conaway ,J.W.: Identification of elongin C and Skp1 sequences that determine cullin selection. J. Biol. Chem. 279: 43019-43026. (2004)

Yada, M., Hatakeyama, S., Kamura, T., Nishiyama, M., Tsunematsu, R., Imaki, H., Ishida, N., Okumura, F., Nakayama, K., Nakayama, K.I.: Phosphorylation- dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J. 23: 2116-2125. (2004)

Hatakeyama, S., Matsumoto, M., Kamura, T., Murayama, M., Du-Hua Chui, Planel, E., Takahashi, R. Nakayama, K.I., Takashima, A.: U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy. J. Neurochem. 91: 299-307. (2004)

Kamura, T., Hara, T., Kotoshiba, S., Yada, M., Ishida, N., Imaki, H., Hatakeyama, S., Nakayama, K., Nakayama, K.I.: Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation. Proc. Natl. Acad. Sci. U S A. 100: 10231-10236. (2003)

Imaki, H., Nakayama, K., Delehouzee, S., Handa, H., Kitagawa, M., Kamura, T., Nakayama, K.I.: Cell cycle-dependent regulation of the Skp2 promoter by GA-binding protein. Cancer Res. 63: 4606-4613. (2003)

Oshikawa, K., Matsumoto, M., Yada, M., Kamura, T., Hatakeyama, S., Nakayama, K.I.: Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1. Biochem. Biophys. Res. Commun. 303:1209-1216. (2003)

Brower, C.S., Sato, S, Tomomori-Sato, .C, Kamura, T., Pause, A., Stearman, R., Klausner, R.D., Malik, S., Lane, W.S., Sorokina, I., Roeder, R.G., Conaway, J.W., Conaway, R.C.: Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Proc. Natl. Acad. Sci. USA. 99:10353-10358. (2002)

Kamura, T., Brower, C.S., Conaway, R.C., Conaway, J.W.: A molecular basis for stabilization of the Von Hippel-Lindau (VHL) tumor suppressor protein by components of the VHL ubiquitin ligase. J. Biol. Chem. 277: 30388-30393. (2002)

Ishida, N., Hara, T., Kamura, T., Yoshida, M., Nakayama, K., Nakayama, K.I. : Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export. J. Biol. Chem. 277: 14355-14358. (2002)

Querido, E., Blanchette, P., Yan, Q., Kamura, T., Morrison, M., Boivin, D., Kaelin ,W.G., Conaway, R.C., Conaway ,J.W., Branton. P.E. : Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex. Genes. Dev., 15:3104-3117. (2001)

Hara, T., Kamura, T., Nakayama, K., Oshikawa, K., Hatakeyama, S., Nakayama, K.-I.: Degradation of p27kip1 at the G0-G1 transition mediated by a Skp2-independent ubiquitination pathway. J. Biol. Chem. 276: 48937-48943. (2001)

Kamura, T., Burian, D., Yan, Q., Schmidt, S.L., Lane, W.S., Querido, E., Branton, P.E., Shilatifard, A., Conaway, R.C., Conaway, J.W.: Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. J. Biol. Chem. 276: 29748-29753. (2001)

Kamura, T., Burian, D., Khalili, H., Schmidt, S. L., Sato, S., Liu, W., Conrad, M. N., Conaway, R. C., Conaway, J. W., Shilatifard, A.: Cloning and characterization of ELL-associated proteins EAP45 and EAP20: A role for yeast EAP-like proteins in regulation of gene expression by glucose. J. Biol. Chem. 276:16528-16533. (2001)

Kamura, T., Sato, S., Iwai, K., Czyzyk-Krzeska, M., Conaway, R. C., Conaway, J. W.: Activation of HIF1 alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc. Natl. Acad. Sci. USA. 97: 10430-10435. (2000)

Brower, C. S., Shilatifard, A., Mather, T., Kamura, T., Takagi, Y., Haque, D., Treharne, A., Foundling, S. I., Conaway, J. W., Conaway, R. C.: The Elongin B ubiquitin homology domain - Identification of Elongin B sequences important for interaction with Elongin C. J. Biol. Chem. 274: 13629-13636. (1999)

Kamura, T., Koepp, D. M., Conrad, M. N., Skowyra, D., Moreland, R. J., Iliopoulos, O., Lane, W. S., Kaelin, W. G., Elledge, S. J., Conaway, R. C., Harper, J. W., Conway, J. W.: Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Science., 284: 657-661. (1999)

Skowyra, D., Koepp, D. M., Kamura, T., Conrad, M. N., Conaway, R. C., Conaway, J. W., Elledge, S. J., Harper, J. W.: Reconstitution of G(1) cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1. Science. 284: 662-665. (1999)

Kamura, T., Conrad, M. N., Yan, Q., Conaway, R. C., Conaway, J. W.: The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2. Genes Dev. 13: 2928-2933. (1999)

Iwai, K., Yamanaka, K., Kamura, T., Minato, N., Conaway, R. C., Canaway, J. W., Klausner, R. D., Pause, A.: Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Proc. Natl. Acad. Sci. USA. 96: 12436-12441. (1999)

Kamura, T., Sato, S., Haque, D., Liu, L., Kaelin, W. G., Conaway, R. C., Conaway, J. W.: The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev. 12: 3872-3881. (1998)

Lonergan, K. M., Iliopoulos, O., Ohh, M., Kamura, T., Conaway, R. C., Conaway, J. W., Kaelin, W. G.: Regulation of Hypoxia-Inducible Genes By the Von-Hippel-Lindau Tumor Suppressor Protein Requires Binding to Complexes Containing Elongins B/C and Cul2. Mol. Cell. Biol. 18: 732-741. (1998)

Kamura, T., Handa, H., Hamasaki, N., Kitajima, S.: Characterization of the Human Thrombopoietin Gene Promoter - a Possible Role of an Ets Transcription Factor, E4tf1/Gabp. J. Biol. Chem., 272: 11361-11368. (1997)

Kamura, T., Tsuda, H., Yae, Y., Hattori, S., Ohga, S., Shibata, Y., Kawabata, S., Hamasaki, N.: An abnormal fibrinogen Fukuoka II (Gly-B b 15-->Cys) characterized by defective fibrin lateral association and mixed disulfide formation. J. Biol. Chem. 270: 29392-29399. (1995)

Kamura, T., Okamura, T., Murakawa, M., Tsuda, H., Teshima, T., Shibuya, T., Harada, M., Niho, Y.: Deficiency of coagulation factor XIII A subunit caused by the dinucleotide deletion at the 5' end of exon III. J. Clin. Invest. 90:315-319. (1992)