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・メンバー
 現在のメンバー
五島剛太・写真
五島 剛太
Gohta Goshima

教授

ggoshima@gmail.com
0599-34-2216(月・火・水・木)
052-788-6174(金・土)

1974年(昭和49年)大阪府豊中市出身
名古屋(9年)と大阪(9年)で育つ

1997年 京都大学理学部卒業
2002年 京都大学大学院理学研究科修了(理学博士)/柳田充弘教授研究室
2002-2007年 カリフォルニア大学サンフランシスコ校(UCSF)/ポスドク Ron Vale教授研究室
2007-2010年 名古屋大学高等研究院 特任准教授
2010年- 名古屋大学大学院理学研究科 教授
2013年  同研究科 生命理学科長
2016-2023年 同研究科 国際連携理学専攻 専攻長
2018年- 同研究科 付属臨海実験所(菅島) 所長
その他の研究歴:
2004-2007年  米国ウッズホール海洋生物学研究所/夏期生理学コース ティーチングアシスタント
2011-2015, 2018年 米国ウッズホール海洋生物学研究所/Whitman Scientist
2016年 サバティカル休暇(エディンバラ大学にて研究)

栗田・写真
栗田 岳歩
Gakuho Kurita

大学院生

kurita.gakuho.b9@s.mail.nagoya-u.ac.jp
0599-34-2216

三重県伊勢市出身、伊勢市育ち

落合・写真
落合 乾大
Kanta Ochiai

大学院生

ochiai.kanta.s1@s.mail.nagoya-u.ac.jp
0599-34-2216

東京都出身、東京 (10年) → 愛知 (10年〜)

小河 華美
Harumi Ogawa

大学院生

ogawa.harumi.c7@s.mail.nagoya-u.ac.jp
0599-34-2216

岐阜県岐阜市出身、岐阜市育ち

足立 恭果
Kyoka Adachi

学部4年生

adachi.kyoka.e2@s.mail.nagoya-u.ac.jp
0599-34-2216

愛知県春日井市出身、春日井市育ち

稲葉理絵・写真
稲葉 理絵
Rie Inaba

ラボマネージャー

smilie@bio.nagoya-u.ac.jp
052-747-6590

 過去のメンバー
卒業生(理学博士)

現所属:中国科学院・Associate professor
論文リスト:
Gluszek AA*, Cullen CF*, Li W*, Battaglia RA, Radford SJ, Costa MF, McKim KS, Goshima G and Ohkura H. (2015) "The microtubule catastrophe promoter Sentin delays stable kinetochore-microtubule attachment in oocytes." J. Cell Biol. 211(6):1113-1120 *equal contribution
>>Link
Li W, Moriwaki T, Tani T, Watanabe T, Kaibuchi K, Goshima G. (2012) "Reconstitution of dynamic microtubules with Drosophila XMAP215, EB1, and Sentin" J. Cell Biol.199(5):849-62
>>Link
Li W, Miki T, Watanabe T, Kakeno M, Sugiyama I, Kaibuchi K, Goshima G. (2011) "EB1 promotes microtubule dynamics by recruiting Sentin in Drosophila cells." J. Cell Biol. 193:973-83. (cover)
>>Link
現所属:高知大学特任助教(URA)
論文リスト:
Yamada M, Miki T, Goshima G. (2016) "Imaging mitosis in the moss Physcomitrella patens. " Methods Mol Biol. 1413:263-282
>>Link
Miki T*, Nakaoka Y*, Goshima G. (2016) "Live cell microscopy-based RNAi screening in the moss Physcomitrella patens. " Methods Mol Biol. 1470:225-246 *equal contribution
>>Link
Miki T, Nishina M, Goshima G. (2015) "RNAi screening identifies the armadillo repeat-containing kinesins responsible for microtubule-dependent nuclear positioning in Physcomitrella patens. " Plant Cell Physiol.
>>Link
Miki T, Naito H, Nishina M, Goshima G. (2014) "Endogenous localizome identifies 43 mitotic kinesins in a plant cell." Proc Natl Acad Sci U S A. 10.1073/pnas.1311243111
>>Link
Nakaoka Y*, Miki T*, Fujioka R, Uehara R, Tomioka A, Obuse C, Kubo M, Hiwatashi Y, Goshima G. (2012) "An inducible RNA interference system in Physcomitrella patens reveals a dominant role of augmin in phragmoplast microtubule generation." Plant Cell. 24(4):1478-93. Epub 2012 Apr 13. *equal contribution
>>Link
Li W, Miki T, Watanabe T, Kakeno M, Sugiyama I, Kaibuchi K, Goshima G. (2011) "EB1 promotes microtubule dynamics by recruiting Sentin in Drosophila cells." J. Cell Biol. 193:973-83. (cover)
>>Link
現所属:第一三共株式会社
論文リスト:
Miki T*, Nakaoka Y*, Goshima G. (2016) "Live cell microscopy-based RNAi screening in the moss Physcomitrella patens." Methods Mol Biol. 1470:225-246 *equal contribution
>>Link
Nakaoka Y, Kimura A, Tani T, Goshima G. (2015) "Cytoplasmic nucleation and atypical branching nucleation generate endoplasmic microtubules in Physcomitrella patens. " Plant Cell. 27(1):228-242.
>>Link
Nakaoka Y*, Miki T*, Fujioka R, Uehara R, Tomioka A, Obuse C, Kubo M, Hiwatashi Y, Goshima G. (2012) "An inducible RNA interference system in Physcomitrella patens reveals a dominant role of augmin in phragmoplast microtubule generation." Plant Cell. 24(4):1478-93. Epub 2012 Apr 13. *equal contribution
>>Link

日本語総説リスト:
中岡由貴上原亮太(2013) 「動物と植物におけるオーグミンの分裂期スピンドル形成への寄与 」 細胞工学 32:263-268
現所属:鳥取大学大学院医学系研究科 機能再生医科学専攻・助教
論文リスト:
Moriwaki T, Goshima G. (2016) "Five factors can reconstitute all three phases of microtubule polymerization dynamics" J. Cell Biol. 215(3):357-368
>>Link
bioRxiv
>>Link
Li W, Moriwaki T, Tani T, Watanabe T, Kaibuchi K, Goshima G. (2012) "Reconstitution of dynamic microtubules with Drosophila XMAP215, EB1, and Sentin" J. Cell Biol. 199(5):849-62
>>Link
現所属:中外製薬株式会社
論文リスト:
Tungadi EA*, Ito A*, Kiyomitsu T, Goshima G. (2017) "Human microcephaly ASPM protein is a spindle pole-focusing factor that functions redundantly with CDK5RAP2." J. Cell Sci. 130:3676-3684 *equal contribution
>>Link
Ito A, Goshima G. (2015) "Microcephaly protein Asp focuses the minus ends of spindle microtubules at the pole and within the spindle." J. Cell Biol. 211(5):999-1009
>>Link
現所属:株式会社Happy Quality
論文リスト:
Leong SY, Edzuka T, Goshima G, Yamada M. (2020)
Kinesin-13 and Kinesin-8 Function during Cell Growth and Division in the Moss Physcomitrella patens
Plant Cell. 32(3):683-702
>>Link
Edzuka T, Goshima G. (2019)
Drosophila kinesin-8 stabilizes the kinetochore–microtubule interaction.
J. Cell Biol. 218(2):474-488
>>Link
bioRxiv
>>Link
Edzuka T, Yamada L, Kanamaru K, Sawada H, Goshima G. (2014)
Identification of the augmin complex in the filamentous fungus Aspergillus nidulans.
PLoS One. 9(7):e101471
>>Link
現所属:名古屋大学
論文リスト:
Leong SY, Edzuka T, Goshima G, Yamada M. (2020)
Kinesin-13 and Kinesin-8 Function during Cell Growth and Division in the Moss Physcomitrella patens
Plant Cell. 32(3):683-702
Yoshida MW, Yamada M, Goshima G. (2019)
Moss Kinesin-14 KCBP Accelerates Chromatid Motility in Anaphase
Cell Struct Funct. 44(2):95-104
Yamada M, Goshima G. (2018)
The KCH Kinesin Drives Nuclear Transport and Cytoskeletal Coalescence to Promote Tip Cell Growth in Physcomitrella patens
Plant Cell. 30(7):1496-1510
Leong SY, Yamada M, Yanagisawa N, Goshima G. (2018)
SPIRAL2 Stabilises Endoplasmic Microtubule Minus Ends in the Moss Physcomitrella patens
Cell Struct Funct. 43(1):53-60
Kosetsu K, Murata T, Yamada M, Nishina M, Boruc J, Hasebe M, Van Damme D, Goshima G. (2017)
Cytoplasmic MTOCs control spindle orientation for asymmetric cell division in plants
Proc Natl Acad Sci U S A. 114(42):E8847-E8854
Yamada M, Tanaka-Takiguchi Y, Hayashi M, Nishina M, Goshima G. (2017)
Multiple kinesin-14 family members drive microtubule minus-end-directed transport in plant cells
J. Cell Biol. 216(6):1705-1714
Yamada M, Goshima G. (2017)
Mitotic Spindle Assembly in Land Plants: Molecules and Mechanisms
Biology (Basel). 6(1)
Yamada M, Miki T, Goshima G. (2016)
Imaging mitosis in the moss Physcomitrella patens
Methods Mol Biol. 1413:263-282
Jonsson E, Yamada M, Vale RD, Goshima G. (2015)
Clustering of a kinesin-14 motor enables processive retrograde microtubule-based transport in plants
Nat Plants. 1: 15087
現所属:ノーベルファーマ株式会社
論文リスト:
Tsuchiya K, Goshima G. (2021)
Microtubule-associated proteins promote microtubule generation in the absence of γ-tubulin in human colon cancer cells
J Cell Biol. 220(12):e202104114
>>Link
Tsuchiya K, Hayashi H, Nishina M, Okumura M, Kanemaki MT, Goshima G, Kiyomitsu T. (2021)
Ran-GTP is non-essential to activate NuMA for mitotic spindle-pole focusing, but dynamically regulates and maintains HURP near chromosomes.
Curr Biol. 31(1):115-127
>>Link
現所属:日清食品株式会社
論文リスト:
Kim J, Goshima G. (2022)
Mitotic spindle formation in the absence of Polo kinase
Proc Natl Acad Sci U S A. 119(12):e2114429119
>>Link
現所属:株式会社バッカス・バイオイノベーション
論文リスト:
Tungadi EA*, Ito A*, Kiyomitsu T, Goshima G. (2017)
Human microcephaly ASPM protein is a spindle pole-focusing factor that functions redundantly with CDK5RAP2
J. Cell Sci. 130:3676-3684
*equal contribution
現所属:Institut Curie, Paris
論文リスト:
Yoshida MW, Oguri N, Goshima G. (2023)
Physcomitrium patens SUN2 mediates MTOC association to the nuclear envelope and facilitates chromosome alignment during spindle assembly
Plant Cell Physiol. 64(9):1106-1117
Yoshida MW, Hakozaki M, Goshima G. (2023)
Armadillo repeat-containing kinesin represents the versatile plus-end-directed transporter in Physcomitrella
Nat Plants. 9(5):733-748
Ta KN*, Yoshida MW*, Tezuka T, Shimizu-Sato S, Nosaka-Takahashi M, Toyoda A, Suzuki T, Goshima G, Sato Y. (2023)
Control of plant cell growth and proliferation by MO25A, a conserved major component of the Mammalian Sterile20-like kinase pathway
Plant and Cell Physiology. 64(3):336-351
*equal contribution
Yoshida MW, Kozgunova E. (2023)
Microfluidic Device for High-Resolution Cytoskeleton Imaging and Washout Assays in Physcomitrium (Physcomitrella) patens.
Methods Mol Biol. 2604:143-158
Kozgunova E, Yoshida MW, Reski R, Goshima G. (2022)
Spindle motility skews division site determination during asymmetric cell division in Physcomitrella
Nat Commun. 13(1):2488
Yoshida MW, Yamada M, Goshima G. (2019)
Moss Kinesin-14 KCBP Accelerates Chromatid Motility in Anaphase
Cell Struct Funct. 44(2):95-104

ポスドク・助教・講師・准教授

現所属:北海道大学 創成研究機構
論文リスト:
Uehara R, Kamasaki T, Hiruma S, Poser I, Yoda K, Yajima J, Gerlich DW, Goshima G. (2016) "Augmin shapes the anaphase spindle for efficient cytokinetic furrow ingression and abscission." Mol. Biol. Cell. 27(5):812-827
>>Link
Uehara R, Tsukada Y, Kamasaki T, Poser I, Yoda K, Gerlich DW, Goshima G.(2013) "Aurora B and Kif2A control microtubule length for assembly of a functional central spindle during anaphase." J. Cell Biol. 202(4):623-36
>>Link
Nakaoka Y*, Miki T*, Fujioka R, Uehara R, Tomioka A, Obuse C, Kubo M, Hiwatashi Y, Goshima G. (2012) "An inducible RNA interference system in Physcomitrella patens reveals a dominant role of augmin in phragmoplast microtubule generation." Plant Cell. 24(4):1478-93. Epub 2012 Apr 13. *equal contribution
>>Link
Uehara R, Goshima G. (2010) "Functional central spindle assembly requires de novo microtubule generation in the interchromosomal region during anaphase." J. Cell Biol. 191:259-267. (cover)
>>Link
Uehara R, Goshima G, Mabuchi I, Vale RD, Spudich JA, Griffis ER. (2010) "Determinants of myosin II cortical localization during cytokinesis." Curr. Biol. 20:1080-1085.
>>Link
Uehara R, Nozawa RS, Tomioka A, Petry S, Vale RD, Obuse C, Goshima G.(2009) "The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells." Proc Natl Acad Sci U S A. 106:6998-7003.
>>Link

日本語総説リスト:

中岡由貴上原亮太(2013)「動物と植物におけるオーグミンの分裂期スピンドル形成への寄与」 細胞工学 32:263-268
上原亮太五島剛太 (2010)「分裂期スピンドル形成における微小管生成機構 」 細胞工学 29:885-889
上原亮太五島剛太 (2009)「オーグミン複合体による細胞分裂期スピンドルの形成機構 」 蛋白質核酸酵素 54(14):1850-1855
現所属:北海道大学 遺伝子病制御研究所 分子腫瘍分野
論文リスト:
Uehara R, Kamasaki T, Hiruma S, Poser I, Yoda K, Yajima J, Gerlich DW, Goshima G. (2016) "Augmin shapes the anaphase spindle for efficient cytokinetic furrow ingression and abscission." Mol. Biol. Cell. 27(5):812-827
>>Link
Uehara R, Tsukada Y, Kamasaki T, Poser I, Yoda K, Gerlich DW, Goshima G. (2013) "Aurora B and Kif2A control microtubule length for assembly of a functional central spindle during anaphase." J. Cell Biol. 202(4):623-36
>>Link
Kamasaki T, O'Toole E, Kita S, Osumi M, Usukura J, McIntosh JR, Goshima G. (2013) "Augmin-dependent microtubule nucleation at microtubule walls in the spindle." J. Cell Biol. 202(1):25-33
>>Link

日本語総説リスト:
釜崎とも子上原亮太(2013)「紡錘体微小管の生成メカニズムに関する微細構造学的解析」 顕微鏡 48-2
現所属:株式会社理研鼎業
論文リスト:
Kosetsu K, Murata T, Yamada M, Nishina M, Boruc J, Hasebe M, Van Damme D, Goshima G. (2017) "Cytoplasmic MTOCs control spindle orientation for asymmetric cell division in plants." Proc Natl Acad Sci U S A. 114(42):E8847-E8854
>>Link
Kosetsu K, de Keijzer J, Janson ME, Goshima G. (2013) "MICROTUBULE-ASSOCIATED PROTEIN65 is essential for maintenance of phragmoplast bipolarity and formation of the cell plate in Physcomitrella patens." Plant Cell. 25(11):4479-92
>>Link
現所属:第一三共株式会社
論文リスト:
Watanabe S, Shioi G, Furuta Y, Goshima G. (2016) "Intra-spindle Microtubule Assembly Regulates Clustering of Microtubule-Organizing Centers during Early Mouse Development" Cell Rep. 15(1):54-60
>>Link
Watanabe S, Goshima G. (2014) "Friction on MAP Determines Its Traveling Direction on Microtubules." Dev Cell. 29(1):5-6 (Review)
>>Link
Watanabe S, De Zan T, Ishizaki T, Yasuda S, Kamijo H, Yamada D, Aoki T, Kiyonari H, Kaneko H, Shimizu R, Yamamoto M, Goshima G, Narumiya S. (2013) "Loss of a Rho-Regulated Actin Nucleator, mDia2, Impairs Cytokinesis during Mouse Fetal Erythropoiesis." Cell Rep. 5(4):926-932
>>Link
現所属:名古屋大学
論文リスト:
Kozgunova E, Yoshida MW, Goshima G. (2020) "Spindle position dictates division site during asymmetric cell division in moss" bioRxiv
>>Link
Kozgunova E, Goshima G. (2019) "A versatile microfluidic device for highly inclined thin illumination microscopy in the moss Physcomitrella patens"Sci Rep. 9(1):15182
>>Link
Kozgunova E, Nishina M, Goshima G. (2019) "Kinetochore protein depletion underlies cytokinesis failure and somatic polyploidization in the moss Physcomitrella patens" eLife pii:e43652
>>Link
現所属:沖縄科学技術大学院大学(OIST)
>>https://researchmap.jp/tomomi.kiyomitsu
現所属:Biotech company, UK
現所属:四川大学(グループリーダー)
論文リスト:
Yi P, Goshima G. (2020)
Rho of Plants GTPases and Cytoskeletal Elements Control Nuclear Positioning and Asymmetric Cell Division during Physcomitrella patens Branching.
Curr Biol. 30(14):2860-2868
>>Link
Yi P, Goshima G. (2020)
Transient cotransformation of CRISPR/Cas9 and oligonucleotide templates enables efficient editing of target loci in Physcomitrella patens.
Plant Biotechnol J. 18(3):599-601
>>Link
Yi P, Goshima G. (2018)
Microtubule nucleation and organization without centrosomes.
Curr Opin Plant Biol. 46:1-7
>>Link
現所属:株式会社Happy Quality
論文リスト:
Leong SY, Edzuka T, Goshima G, Yamada M. (2020)
Kinesin-13 and Kinesin-8 Function during Cell Growth and Division in the Moss Physcomitrella patens
Plant Cell. 32(3):683-702
>>Link
Edzuka T, Goshima G. (2019)
Drosophila kinesin-8 stabilizes the kinetochore–microtubule interaction.
J. Cell Biol. 218(2):474-488
>>Link
bioRxiv
>>Link
Edzuka T, Yamada L, Kanamaru K, Sawada H, Goshima G. (2014)
Identification of the augmin complex in the filamentous fungus Aspergillus nidulans.
PLoS One. 9(7):e101471
>>Link

技術補助員

論文リスト:
Nakaoka Y*, Miki T*, Fujioka R, Uehara R, Tomioka A, Obuse C, Kubo M, Hiwatashi Y, Goshima G. (2012) "An inducible RNA interference system in Physcomitrella patens reveals a dominant role of augmin in phragmoplast microtubule generation." Plant Cell.2012 Apr;24(4):1478-93. Epub 2012 Apr 13. *equal contribution
>>Link
Uehara R, Nozawa RS, Tomioka A, Petry S, Vale RD, Obuse C, Goshima G.(2009) "The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells." Proc Natl Acad Sci U S A. 106:6998-7003.
>>Link
論文リスト:
Kozgunova E, Nishina M, Goshima G. (2019) "Chromosome missegregation causes somatic polyploidization in plants" eLife pii:e43652
>>Link
Kosetsu K, Murata T, Yamada M, Nishina M, Boruc J, Hasebe M, Van Damme D, Goshima G. (2017) "Cytoplasmic MTOCs control spindle orientation for asymmetric cell division in plants." Proc Natl Acad Sci U S A. 114(42):E8847-E8854
>>Link
Yamada M, Tanaka-Takiguchi Y, Hayashi M, Nishina M, Goshima G. (2017) "Multiple kinesin-14 family members drive microtubule minus-end-directed transport in plant cells" J. Cell Biol. 216(6):1705-1714
>>Link
bioRxiv
>>Link
Miki T, Nishina M, Goshima G. (2015) "RNAi screening identifies the armadillo repeat-containing kinesins responsible for microtubule-dependent nuclear positioning in Physcomitrella patens. " Plant Cell Physiol. 56(4):737-749
>>Link
Miki T, Naito H, Nishina M, Goshima G. (2014) "Endogenous localizome identifies 43 mitotic kinesins in a plant cell." Proc Natl Acad Sci U S A. 10.1073/pnas.1311243111
>>Link