College: Kyoto University (Faculty of Science)
Ph.D: Department of Biophysics, Kyoto University, 2002 (Prof. Mitsuhiro Yanagida’s lab)
Post-doc: Ron Vale’s lab at UCSF (2002-2007)
Designated Associate Professor: Institute for Advanced Research, Nagoya University (2007 – 2010)
Professor: Division of Biological Science, Graduate School of Science, Nagoya University (2010 - current)
Other research activities:
Teaching assistant, Physiology course, Woods Hole, USA (2004-2007)
Whitman Scientist, MBL, Woods Hole, USA (2011-15, 2018)
Sabbatical leave (University of Edinburgh, 2016)
Publications：
Gluszek AA*, Cullen CF*, Li W*, Battaglia RA, Radford SJ, Costa MF, McKim KS, Goshima G and Ohkura H. (2015) "The microtubule catastrophe promoter Sentin delays stable kinetochore-microtubule attachment in oocytes." J. Cell Biol. 211(6):1113-1120 *equal contribution >>Link Li W, Moriwaki T, Tani T, Watanabe T, Kaibuchi K, Goshima G. (2012) "Reconstitution of dynamic microtubules with Drosophila XMAP215, EB1, and Sentin" J. Cell Biol.199(5):849-62 >>Link Li W, Miki T, Watanabe T, Kakeno M, Sugiyama I, Kaibuchi K, Goshima G. (2011) "EB1 promotes microtubule dynamics by recruiting Sentin in Drosophila cells." J. Cell Biol. 193:973-83. (cover) >>Link
Publications： Yamada M, Miki T,
Goshima G. (2016) "Imaging mitosis in the moss Physcomitrella patens. "
Methods Mol Biol. 1413:263-282 >>Link Miki T*, Nakaoka Y*,
Goshima G. (2016) "Live cell microscopy-based RNAi screening in the moss Physcomitrella patens. " Methods Mol Biol. 1470:225-246 *equal contribution >>Link Miki T, Nishina M,
Goshima G. (2015) "RNAi screening identifies the armadillo repeat-containing kinesins responsible for microtubule-dependent nuclear positioning in Physcomitrella patens. " Plant Cell Physiol. >>Link Miki T, Naito H, Nishina M,
Goshima G. (2014) "Endogenous localizome identifies 43 mitotic kinesins in a plant cell." Proc Natl Acad Sci U S A. 10.1073/pnas.1311243111 >>Link Nakaoka Y*, Miki T*, Fujioka R, Uehara R, Tomioka A, Obuse C, Kubo M, Hiwatashi Y, Goshima G. (2012) "An inducible RNA interference system in Physcomitrella patens reveals a dominant role of augmin in phragmoplast microtubule generation." Plant Cell. 24(4):1478-93. Epub 2012 Apr 13. *equal contribution >>Link Li W, Miki T, Watanabe T, Kakeno M, Sugiyama I, Kaibuchi K, Goshima G. (2011) "EB1 promotes microtubule dynamics by recruiting Sentin in Drosophila cells." J. Cell Biol. 193:973-83. (cover) >>Link
Publications： Miki T*, Nakaoka Y*,
Goshima G. (2016) "Live cell microscopy-based RNAi screening in the moss Physcomitrella patens."
Methods Mol Biol. 1470:225-246 *equal contribution >>Link Nakaoka Y, Kimura A, Tani T,
Goshima G. (2015) "Cytoplasmic nucleation and atypical branching nucleation generate endoplasmic microtubules in Physcomitrella patens. " Plant Cell. 27(1):228-242. >>Link Nakaoka Y*, Miki T*, Fujioka R, Uehara R, Tomioka A, Obuse C, Kubo M, Hiwatashi Y, Goshima G. (2012) "An inducible RNA interference system in Physcomitrella patens reveals a dominant role of augmin in phragmoplast microtubule generation." Plant Cell. 24(4):1478-93. Epub 2012 Apr 13. *equal contribution >>Link
Publications： Moriwaki T,
Goshima G. (2016) "Five factors can reconstitute all three phases of microtubule polymerization dynamics" J. Cell Biol. 215(3):357-368 >>Link bioRxiv >>Link Li W, Moriwaki T, Tani T, Watanabe T, Kaibuchi K,
Goshima G. (2012) "Reconstitution of dynamic microtubules with Drosophila XMAP215, EB1, and Sentin" J. Cell Biol. 199(5):849-62 >>Link
Publications： Tungadi EA*, Ito A*, Kiyomitsu T,
Goshima G. (2017) "Human microcephaly ASPM protein is a spindle pole-focusing factor that functions redundantly with CDK5RAP2." J. Cell Sci. 130:3676-3684 *equal contribution >>Link Ito A, Goshima G. (2015) "Microcephaly protein Asp focuses the minus ends of spindle microtubules at the pole and within the spindle." J. Cell Biol. 211(5):999-1009 >>Link
Publications： Leong SY, Edzuka T, Goshima G, Yamada M. (2020)
Kinesin-13 and Kinesin-8 Function during Cell Growth and Division in the Moss Physcomitrella patens
Plant Cell. 32(3):683-702 >>Link Edzuka T,
Goshima G. (2019)
Drosophila kinesin-8 stabilizes the kinetochore–microtubule interaction.
J. Cell Biol. 218(2):474-488 >>Link bioRxiv >>Link Edzuka T, Yamada L, Kanamaru K, Sawada H,
Goshima G. (2014)
Identification of the augmin complex in the filamentous fungus Aspergillus nidulans. PLoS One. 9(7):e101471 >>Link
Publications： Tsuchiya K, Goshima G. (2021)
Microtubule-associated proteins promote microtubule generation in the absence of γ-tubulin in human colon cancer cells
J Cell Biol. 220(12):e202104114 >>Link Tsuchiya K, Hayashi H, Nishina M, Okumura M, Kanemaki MT,
Goshima G, Kiyomitsu T. (2021)
Ran-GTP is non-essential to activate NuMA for mitotic spindle-pole focusing, but dynamically regulates and maintains HURP near chromosomes.
Curr Biol. 31(1):115-127 >>Link
Publications： Kim J, Goshima G. (2022)
Mitotic spindle formation in the absence of Polo kinase
Proc Natl Acad Sci U S A. 119(12):e2114429119 >>Link
Publications： Uehara R, Kamasaki T, Hiruma S, Poser I, Yoda K, Yajima J, Gerlich DW,
Goshima G. (2016) "Augmin shapes the anaphase spindle for efficient cytokinetic furrow ingression and abscission." Mol. Biol. Cell. 27(5):812-827 >>Link Uehara R, Tsukada Y, Kamasaki T, Poser I, Yoda K, Gerlich DW,
Goshima G.(2013) "Aurora B and Kif2A control microtubule length for assembly of a functional central spindle during anaphase." J. Cell Biol. 202(4):623-36 >>Link Nakaoka Y*, Miki T*, Fujioka R, Uehara R, Tomioka A, Obuse C, Kubo M, Hiwatashi Y, Goshima G. (2012) "An inducible RNA interference system in Physcomitrella patens reveals a dominant role of augmin in phragmoplast microtubule generation." Plant Cell. 24(4):1478-93. Epub 2012 Apr 13. *equal contribution >>Link Uehara R, Goshima G. (2010) "Functional central spindle assembly requires de novo microtubule generation in the interchromosomal region during anaphase." J. Cell Biol. 191:259-267. (cover) >>Link Uehara R, Goshima G, Mabuchi I, Vale RD, Spudich JA, Griffis ER. (2010) "Determinants of myosin II cortical localization during cytokinesis." Curr. Biol. 20:1080-1085. >>Link Uehara R, Nozawa RS, Tomioka A, Petry S, Vale RD, Obuse C, Goshima G.(2009) "The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells." Proc Natl Acad Sci U S A. 106:6998-7003.
>>Link
Publications： Uehara R, Kamasaki T, Hiruma S, Poser I, Yoda K, Yajima J, Gerlich DW, Goshima G. (2016) "Augmin shapes the anaphase spindle for efficient cytokinetic furrow ingression and abscission." Mol. Biol. Cell. 27(5):812-827 >>Link Uehara R, Tsukada Y, Kamasaki T, Poser I, Yoda K, Gerlich DW, Goshima G. (2013) "Aurora B and Kif2A control microtubule length for assembly of a functional central spindle during anaphase." J. Cell Biol. 202(4):623-36 >>Link Kamasaki T, O'Toole E, Kita S, Osumi M, Usukura J, McIntosh JR, Goshima G. (2013) "Augmin-dependent microtubule nucleation at microtubule walls in the spindle." J. Cell Biol. 202(1):25-33 >>Link
Publications： Kosetsu K, Murata T, Yamada M, Nishina M, Boruc J, Hasebe M, Van Damme D,
Goshima G. (2017) "Cytoplasmic MTOCs control spindle orientation for asymmetric cell division in plants." Proc Natl Acad Sci U S A. 114(42):E8847-E8854 >>Link Kosetsu K, de Keijzer J, Janson ME,
Goshima G. (2013) "MICROTUBULE-ASSOCIATED PROTEIN65 is essential for maintenance of phragmoplast bipolarity and formation of the cell plate in Physcomitrella patens." Plant Cell. 25(11):4479-92 >>Link
Publications： Watanabe S, Shioi G, Furuta Y,
Goshima G. (2016) "Intra-spindle Microtubule Assembly Regulates Clustering of Microtubule-Organizing Centers during Early Mouse Development" Cell Rep. 15(1):54-60 >>Link Watanabe S, Goshima G. (2014) "Friction on MAP Determines Its Traveling Direction on Microtubules." Dev Cell. 29(1):5-6 (Review) >>Link Watanabe S, De Zan T, Ishizaki T, Yasuda S, Kamijo H, Yamada D, Aoki T, Kiyonari H, Kaneko H, Shimizu R, Yamamoto M, Goshima G, Narumiya S. (2013) "Loss of a Rho-Regulated Actin Nucleator, mDia2, Impairs Cytokinesis during Mouse Fetal Erythropoiesis." Cell Rep. 5(4):926-932 >>Link
Publications： Kozgunova E, Yoshida MW, Goshima G. (2020) "Spindle position dictates division site during asymmetric cell division in moss" bioRxiv >>Link Kozgunova E,
Goshima G. (2019) "A versatile microfluidic device for highly inclined thin illumination microscopy in the moss Physcomitrella patens"Sci Rep. 9(1):15182 >>Link Kozgunova E, Nishina M,
Goshima G. (2019) "Kinetochore protein depletion underlies cytokinesis failure and somatic polyploidization in the moss Physcomitrella patens" eLife pii:e43652 >>Link
Publications： Yi P, Goshima G. (2020)
Rho of Plants GTPases and Cytoskeletal Elements Control Nuclear Positioning and Asymmetric Cell Division during Physcomitrella patens Branching.
Curr Biol. 30(14):2860-2868 >>Link Yi P,
Goshima G. (2020)
Transient cotransformation of CRISPR/Cas9 and oligonucleotide templates enables efficient editing of target loci in Physcomitrella patens.
Plant Biotechnol J. 18(3):599-601 >>Link Yi P,
Goshima G. (2018)
Microtubule nucleation and organization without centrosomes.
Curr Opin Plant Biol. 46:1-7 >>Link
Publications： Leong SY, Edzuka T, Goshima G, Yamada M. (2020)
Kinesin-13 and Kinesin-8 Function during Cell Growth and Division in the Moss Physcomitrella patens
Plant Cell. 32(3):683-702 >>Link Edzuka T,
Goshima G. (2019)
Drosophila kinesin-8 stabilizes the kinetochore–microtubule interaction.
J. Cell Biol. 218(2):474-488 >>Link bioRxiv >>Link Edzuka T, Yamada L, Kanamaru K, Sawada H,
Goshima G. (2014)
Identification of the augmin complex in the filamentous fungus Aspergillus nidulans. PLoS One. 9(7):e101471 >>Link
Publications： Nakaoka Y*, Miki T*, Fujioka R, Uehara R, Tomioka A, Obuse C, Kubo M, Hiwatashi Y, Goshima G. (201２) "An inducible RNA interference system in Physcomitrella patens reveals a dominant role of augmin in phragmoplast microtubule generation." Plant Cell.2012 Apr;24(4):1478-93. Epub 2012 Apr 13. *equal contribution >>Link Uehara R, Nozawa RS, Tomioka A, Petry S, Vale RD, Obuse C, Goshima G.(2009) "The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells." Proc Natl Acad Sci U S A.106:6998-7003. >>Link
Publications： Kozgunova E, Nishina M,
Goshima G. (2019) "Chromosome missegregation causes somatic polyploidization in plants" eLife pii:e43652 >>Link Kosetsu K, Murata T, Yamada M, Nishina M, Boruc J, Hasebe M, Van Damme D,
Goshima G. (2017) "Cytoplasmic MTOCs control spindle orientation for asymmetric cell division in plants." Proc Natl Acad Sci U S A. 114(42):E8847-E8854 >>Link Yamada M, Tanaka-Takiguchi Y, Hayashi M, Nishina M,
Goshima G. (2017) "Multiple kinesin-14 family members drive microtubule minus-end-directed transport in plant cells" J. Cell Biol. 216(6):1705-1714 >>Link bioRxiv >>Link Miki T, Nishina M,
Goshima G. (2015) "RNAi screening identifies the armadillo repeat-containing kinesins responsible for microtubule-dependent nuclear positioning in Physcomitrella patens. " Plant Cell Physiol. 56(4):737-749 >>Link Miki T, Naito H, Nishina M,
Goshima G. (2014) "Endogenous localizome identifies 43 mitotic kinesins in a plant cell." Proc Natl Acad Sci U S A. 10.1073/pnas.1311243111 >>Link
