Program
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December 17, 2018
| Opening Remarks | |
| 13:00 ~ 13:10 | Masahide Takahashi (Regent of Nagoya University) |
| Session I: Plenary lecture (Chair: Hisao Masai) | |
| 13:10 ~ 14:00 | Peter Burgers (Washington University School of Medicine, USA) “Fifty Years of Okazaki Fragment Research” |
| Session II: History and implication of Okazaki Fragment/Discontinuous replication model (Chair: Hisao Masai) | |
| 14:00 ~ 14:40 | Robert Fuller (University of Michigan Medical School, USA) “From oriC Replication to Studies of VPS13 and Neurodegeneration” |
| 14:40 ~ 15:05 | Mitsuru Furusawa (Chitose Laboratory) “Okazaki fragment drives evolution” |
| 15:05 ~ 15:25 | Coffee Break |
| Session III: From Okazaki Fragment to new fields (Chair: Takehiko Kobayashi) | |
| 15:25 ~ 15:50 | Hisao Masai (Tokyo Metropolitan Institute of Medical Science) “From mechanisms of primer RNA synthesis to revelation of hidden messages of genome” |
| 15:50 ~ 16:15 | Hisao Masukata (Osaka University) “Replication origin where the first Okazaki fragment initiates” |
| 16:15 ~ 16:40 | Hiroshi Masumoto (Kazusa DNA Res Inst) “Developments of Human Artificial Chromosomes and Chromatin Manipulation Technologies.” |
| 16:40 ~ 17:05 | Fuyuhiko Tamanoi (Kyoto University) “From Okazaki fragments to Patient-derived Tumor Model” |
| 17:05 ~ 17:25 | Tsuneko Okazaki “Discontinuous Mechanism of DNA replication. -How it was investigated.-” |
| 17:25 ~ 17:30 | Photo Session |
| 17:30 ~ 18:00 | Poster Short Presentations |
| 18:00 ~ 19:00 | Poster Viewing with refreshments |
| 19:00 ~ 20:45 | Reception Party (Hananoki) |
December 18, 2018
| Session IV: Okazaki fragment/ Discontinuous Replication now and beyond (Chair: Peter Burgers) | |
| 9:00 ~ 9:25 | Hisaji Maki (Nara Institute of Science and Technology) “Collision with duplex DNA renders Escherichia coli DNA polymerase III holoenzyme susceptible to DNA polymerase IV-mediated polymerase switching on the sliding clamp.” |
| 9:25 ~ 9:50 | Toshiki Tsurimoto (Kyushu University) “Roles of PCNA and clamp loaders for leading and lagging DNA synthesis” |
| 9:50 ~ 10:30 | Philippe Pasero (Institute of Human Genetics, France) “Nascent DNA drives inflammation under replication stress conditions” |
| 10:30 ~ 10:50 | Coffee Break |
| 10:50 ~ 11:15 | Yoshizumi Ishino (Kyushu University) “Replisome structure and its functions in Archaea” |
| 11:15 ~ 11:55 | Huilin Li (Van Andel Research Institute, USA) “Cryo-EM suggests a coupled-sister-replisomes model at the core of the replication factory” |
| 11:55 ~ 13:00 | Lunch Break |
| Session V: The newest trends in DNA replication and related areas after Okazaki Fragment/ Discontinuous replication model (Chair: Katsuhiko Shirahige) | |
| 13:00 ~ 13:25 | Tsutomu Katayama (Kyushu University) “Mechanisms and regulations in the initiator DnaA and the initiation complex” |
| 13:25 ~ 13:50 | Hiroyuki Araki (National Institute of Genetics) “A novel role of DNA polymerase epsilon at replication forks; its involvement in replication fork pausing at the barriers.” |
| 13:50 ~ 14:15 | Takehiko Kobayashi (The University of Tokyo) “Replication fork arrest induces gene amplification and cellular senescence” |
| 14:15 ~ 14:35 | Coffee Break |
| 14:35 ~ 15:00 | Katsuhiko Shirahige (The University of Tokyo) “Transcriptional Regulation by Cohesin loader” |
| 15:00 ~ 15:25 | Masato Kanemaki (National Institute of Genetics) “Revealing a non-canonical DNA replication important for genome maintenance in human cells” |
| 15:25 ~ | Commendation Ceremony of Student Poster Award |
| Concluding remarks | |
| 15:35 ~ | Hisao Masai |